MovDisordV3, Main, Exploration, bibRecord, 001179

Cardiovascular Physiology in Premotor Parkinson's Disease: A Neuroepidemiologic Study

Identifieur interne : 001179 ( Main/Exploration ); précédent : 001178; suivant : 001180

Cardiovascular Physiology in Premotor Parkinson's Disease: A Neuroepidemiologic Study

Auteurs : Samay Jain [États-Unis] ; Thanh G. Ton [États-Unis] ; Subashan Perera [États-Unis] ; YAN ZHENG [États-Unis] ; Phyllis K. Stein [États-Unis] ; Evan Thacker [États-Unis] ; Elsa S. Strotmeyer [États-Unis] ; Anne B. Newman [États-Unis] ; Will T. Jr Longstreth [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0315949

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Physiologie.

English descriptors

KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Cardiovascular Physiological Processes, Carotid Stenosis (complications), Carotid Stenosis (ultrasonography), Cohort Studies, Data Interpretation, Statistical, Dizziness, Electrocardiography, Female, Heart Rate (physiology), Hospitalization (statistics & numerical data), Humans, Longitudinal Studies, Male, Movement Disorders (complications), Movement Disorders (physiopathology), Nervous system diseases, Neurologic Examination, Parkinson Disease (epidemiology), Parkinson Disease (physiopathology), Parkinson disease, Physiology, Risk.
MESH :
- chemical , adverse effects : Antiparkinson Agents.
- chemical , therapeutic use : Antiparkinson Agents.
- complications : Carotid Stenosis, Movement Disorders.
- epidemiology : Parkinson Disease.
- physiology : Heart Rate.
- physiopathology : Movement Disorders, Parkinson Disease.
- statistics & numerical data : Hospitalization.
- ultrasonography : Carotid Stenosis.
- Aged, Cardiovascular Physiological Processes, Cohort Studies, Data Interpretation, Statistical, Dizziness, Electrocardiography, Female, Humans, Longitudinal Studies, Male, Neurologic Examination, Risk.

Abstract

Changes in cardiovascular physiology in Parkinson's disease (PD) are common and may occur prior to diagnostic parkinsonian motor signs. We investigated associations of electrocardiographic (ECG) abnormalities, orthostasis, heart rate variability, and carotid stenosis with the risk of PD diagnosis in the Cardiovascular Health Study, a community-based cohort of older adults. ECG abnormality, orthostasis (symptomatic or asymptomatic), heart rate variability (24-hour Holter monitoring), and any carotid stenosis (>1%) by ultrasound were modeled as primary predictors of incident PD diagnosis using multivariable logistic regression. Incident PD cases were identified by at least 1 of the following: self-report, antiparkinsonian medication use, and ICD-9. If unadjusted models were significant, they were adjusted or stratified by age, sex, and smoking status, and those in which predictors were still significant (P ≤ .05) were also adjusted for race, diabetes, total cholesterol, low-density lipoprotein, blood pressure, body mass index, physical activity, education level, stroke, and C-reactive protein. Of 5888 participants, 154 incident PD cases were identified over 14 years of follow-up. After adjusting models with all covariates, those with any ECG abnormality (odds ratio [OR], 1.45; 95% Cl, 1.02-2.07; P = .04) or any carotid stenosis (OR, 2.40; 95% Cl, 1.40-4.09; P = .001) at baseline had a higher risk of incident PD diagnosis. Orthostasis and heart rate variability were not significant predictors. This exploratory study suggests that carotid stenosis and ECG abnormalities occur prior to motor signs in PD, thus serving as potential premotor features or risk factors for PD diagnosis. Replication is needed in a population with more thorough ascertainment of PD onset.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652377

Affiliations:

Le document en format XML

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<series><title level="j" type="main">Movement disorders</title>
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<term>Antiparkinson Agents (adverse effects)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Cardiovascular Physiological Processes</term>
<term>Carotid Stenosis (complications)</term>
<term>Carotid Stenosis (ultrasonography)</term>
<term>Cohort Studies</term>
<term>Data Interpretation, Statistical</term>
<term>Dizziness</term>
<term>Electrocardiography</term>
<term>Female</term>
<term>Heart Rate (physiology)</term>
<term>Hospitalization (statistics & numerical data)</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Movement Disorders (complications)</term>
<term>Movement Disorders (physiopathology)</term>
<term>Nervous system diseases</term>
<term>Neurologic Examination</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson disease</term>
<term>Physiology</term>
<term>Risk</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Carotid Stenosis</term>
<term>Movement Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Heart Rate</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Movement Disorders</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Carotid Stenosis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cardiovascular Physiological Processes</term>
<term>Cohort Studies</term>
<term>Data Interpretation, Statistical</term>
<term>Dizziness</term>
<term>Electrocardiography</term>
<term>Female</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Neurologic Examination</term>
<term>Risk</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Physiologie</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Changes in cardiovascular physiology in Parkinson's disease (PD) are common and may occur prior to diagnostic parkinsonian motor signs. We investigated associations of electrocardiographic (ECG) abnormalities, orthostasis, heart rate variability, and carotid stenosis with the risk of PD diagnosis in the Cardiovascular Health Study, a community-based cohort of older adults. ECG abnormality, orthostasis (symptomatic or asymptomatic), heart rate variability (24-hour Holter monitoring), and any carotid stenosis (>1%) by ultrasound were modeled as primary predictors of incident PD diagnosis using multivariable logistic regression. Incident PD cases were identified by at least 1 of the following: self-report, antiparkinsonian medication use, and ICD-9. If unadjusted models were significant, they were adjusted or stratified by age, sex, and smoking status, and those in which predictors were still significant (P ≤ .05) were also adjusted for race, diabetes, total cholesterol, low-density lipoprotein, blood pressure, body mass index, physical activity, education level, stroke, and C-reactive protein. Of 5888 participants, 154 incident PD cases were identified over 14 years of follow-up. After adjusting models with all covariates, those with any ECG abnormality (odds ratio [OR], 1.45; 95% Cl, 1.02-2.07; P = .04) or any carotid stenosis (OR, 2.40; 95% Cl, 1.40-4.09; P = .001) at baseline had a higher risk of incident PD diagnosis. Orthostasis and heart rate variability were not significant predictors. This exploratory study suggests that carotid stenosis and ECG abnormalities occur prior to motor signs in PD, thus serving as potential premotor features or risk factors for PD diagnosis. Replication is needed in a population with more thorough ascertainment of PD onset.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Missouri (État)</li>
<li>Pennsylvanie</li>
<li>Washington (État)</li>
</region>
<settlement><li>Saint-Louis (Missouri)</li>
</settlement>
<orgName><li>École de médecine (Université Washington de Saint-Louis)</li>
</orgName>
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<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Jain, Samay" sort="Jain, Samay" uniqKey="Jain S" first="Samay" last="Jain">Samay Jain</name>
</region>
<name sortKey="Longstreth, Will T Jr" sort="Longstreth, Will T Jr" uniqKey="Longstreth W" first="Will T. Jr" last="Longstreth">Will T. Jr Longstreth</name>
<name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name>
<name sortKey="Perera, Subashan" sort="Perera, Subashan" uniqKey="Perera S" first="Subashan" last="Perera">Subashan Perera</name>
<name sortKey="Stein, Phyllis K" sort="Stein, Phyllis K" uniqKey="Stein P" first="Phyllis K." last="Stein">Phyllis K. Stein</name>
<name sortKey="Strotmeyer, Elsa S" sort="Strotmeyer, Elsa S" uniqKey="Strotmeyer E" first="Elsa S." last="Strotmeyer">Elsa S. Strotmeyer</name>
<name sortKey="Thacker, Evan" sort="Thacker, Evan" uniqKey="Thacker E" first="Evan" last="Thacker">Evan Thacker</name>
<name sortKey="Ton, Thanh G" sort="Ton, Thanh G" uniqKey="Ton T" first="Thanh G." last="Ton">Thanh G. Ton</name>
<name sortKey="Yan Zheng" sort="Yan Zheng" uniqKey="Yan Zheng" last="Yan Zheng">YAN ZHENG</name>
</country>
</tree>
</affiliations>
</record>

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Movement Disorders (revue)

Cardiovascular Physiology in Premotor Parkinson's Disease: A Neuroepidemiologic Study

Cardiovascular Physiology in Premotor Parkinson's Disease: A Neuroepidemiologic Study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.